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Exposure to air pollution as a potential contributor to cognitive function, cognitive decline, brain imaging, and dementia: a systematic review of epidemiologic research

In participants with moderate-to-severe cognitive impairment (defined by MMSE), a larger improvement in cognitive performance was observed for donepezil and memantine, and their combination (donepezil +memantine), and these efficacy-related results are expected to also be reflected when a future study becomes available

Another important direction is the development of combination therapies that simultaneously target ferroptosis and other pro-fibrotic mechanisms

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Lab testing, including G6PD screening (prior to high-dose vitamin C), kidney function, and electrolyte monitoring, is essential to ensure safety