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however, the only statistically significant difference was between the LD control group and both groups switched from WD to LD, regardless of their treatment (Supplementary Fig

Others experience it as a loss of pleasure or mild emotional flatness around food

Evidence from observational studies suggests that with longer symptom duration and more profound B 12 deficiency, the likelihood that neurological symptoms will not completely resolve increases.28 People often continue to experience mild neurological symptoms such as poor memory, impaired concentration, and fatigue even after adequate B 12 replacement (eg, therapy according to the BNF suggested treatment regimen)91729 and many patients report they need additional treatment

The presence of PN in PD subjects has been found to be associated with various factors in two large studies, including the total dosage of LDopa, low serum Vit B12 levels, and elevated Hcy and MMA levels (Ceravolo et al

An additional finding was the significant correlations reported between vitamin B12 intake and total serum B12, methylmalonic acid and holoTC