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These are mechanistic observations from separate preclinical studies, not outcomes confirmed in combination trials

Wiel C, Le Gal K, Ibrahim MX, Jahangir CA, Kashif M, Yao H, Ziegler DV, Xu X, Ghosh T, Mondal T, et al

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Thalamocortical dysfunction and dysrhythmia in chronic pain demonstrated that CLBP pathophysiology and clinical pain intensity are associated with distinct thalamocortical network dynamics
