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When the experiments were repeated with APAP dissolved in saline versus DMSO, it was shown that the presence of DMSO activated NK T-cells and led to a role of these immune cells in the pathophysiology [164]

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In mammals, GSTs were originally classified as cytosolic, mitochondrial and membrane-associated GSTs, the latter being subdivided into microsomal GSTs and leukotriene C 4 synthetases (Kraus, 1980

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