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50 nM of gliotoxin can exert immunosuppressive activity via the suppression of the phagocytosis of astrocytes [24,37], which led us to exploit low-dose gliotoxins as immunosuppressive agents during an organ-transplant operation, thus reducing immunological rejection in organ transplant patients

Results indicated that 279 natural compounds (62 terpenoids, 57 alkaloids, 52 flavonoids, 26 phenols, 19 phenylpropanoids, 9 steroids, 9 saponins, 8 quinonoids, 6 vitamins, and 31 others) can act on various mechanisms to improve UC, such as regulating gut microbiota and metabolites (Mechanisms I), protecting the intestinal mucosal barrier (Mechanisms II), regulating intestinal mucosal immune response (Mechanisms III), as well as the other mechanisms (cellular autophagy modulation and ferroptosis inhibition)

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10.1016/j.cellimm.2007.10.003