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Moreover, due to the differential RT sensitivity among immune cells, RT may cause a direct decrease in the ratio of cytotoxic T cells to regulatory T cells (Tregs) 8 , accompanied by the upregulation of cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) 9

Cancer 27 , 724729 (1991)

When stratified by administration route, the average percentage reductions were: Intramuscular (IM): 48.3% Sublingual: 30.7% Oral: 30.3% These results suggest that IM administration leads the most pronounced homocysteine reduction, however, sublingual and oral routes also demonstrate clinically relevant effects

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