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Degradation of Nrf2 by the 26 S proteasome

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Nature 537:185190 Kruegel AC, Gassaway MM, Kapoor A, Vradi A, Majumdar S, Filizola M, Javitch JA, Sames D (2016) Synthetic and receptor signaling explorations of the mitragyna alkaloids: mitragynine as an atypical molecular framework for opioid receptor modulators