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In cellular and animal models of steroid insensitivity mediated by oxidative stress, S-CMC restored steroid sensitivity by increasing HDAC-2 expression/activity through elevating GSH and SOD levels, reducing oxidative stress, enhancing HDAC-2 recruitment and reducing H4 acetylation in the IL-8 promoter region, and eventually alleviating inflammation and lung damage [88, 89]

(1980) was published on the neuropsychiatric manifestations in megaloblastic anemia that occurred due to low folate or vitamin B12 levels

Our review of the 112 children with ASD/MD reported in the medical literature found several distinct clinical characteristics in this group, such as developmental regression, seizures, motor delay, GI abnormalities, and a higher prevalence of elevated lactate and pyruvate, as compared with the general ASD population

J Med Plants Res 6(46):57145719 Asghar HA, Abbas SQ, Arshad MK, Jabin A, Usman B, Aslam M, Asghar A (2022) Therapeutic potential of Azadirachta indica (Neem): a comprehensive review