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The ingestion of a high-calorie diet or the consumption of substantial amounts of alcohol has been demonstrated to promote DNL through the activation of two transcription factors: carbohydrate response element binding protein (ChREBP) and sterol regulatory element binding protein-1c (SREBP-1c)

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NAD+ injections' impact on intracellular and compartmental NAD+ pools, however, is not yet known (1)

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