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This observed result was achieved by reducing mitochondrial membrane potential, increasing ROS levels in mitochondria, upregulating pro-apoptotic genes (Bad, Bid, Caspase-9, and Caspase-3), and downregulating the anti-apoptotic Bcl2 gene ( Silver nanoparticles (AgNPs) have emerged as promising candidates for cancer therapy due to their nanoscale size and their ability to induce cell death through mechanisms such as oxidative stress, chromosomal instability, and ds DNA break ( Fagonia indica , which effectively inhibit the growth of MCF-7 breast cancer cells in a concentration-dependent manner, with an IC50 value of 12.35g/mL

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[PubMed] [Google Scholar] Mezey E, Eisenhofer G, Hansson S, Hunyady B, Hoffman BJ (1998) Dopamine produced by the stomach may act as a paracrine/autocrine hormone in the rat