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Also, methylmalonic acid levels can be elevated in patients with renal disease (the result of decreased urinary excretion)

The myriad trigger-RNA-induced interactions specifying substrate recognition by the ZSWIM8 E3 ligase do not correspond to a traditional degron motif 14,15

Sasaki K, Kantarjian HM, Luthra R, Patel KP, Garcia-Manero G, Verstovsek S, Estey EH, Kadia T, Brandt M, Pierce S, Estrov Z, Ferrajoli A, Borthakur G , Cortes JE, Ravandi F