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Background: Lafora Progressive Myoclonic Epilepsy, or Lafora disease (LD), is a rare fatal form of progressive myoclonic epilepsies with typically adolescent onset and shortened life expectancy, within 10 years after onset

Slices were co-labelled with Myelin Basic Protein (MBP) [1:100, MAB386] and Myelin Oligodendrocyte Glycoprotein (MOG) [1:250, ab233549] ( n = 3 slices per timepoint and treatment)

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Abbreviations BMNPs: Biogenic Metallic Nanoparticles COSY: Correlation Spectroscopy CAM: Crassulacean Acid Metabolism HMBC: Heteronuclear Multiple Bond Correlation Spectroscopy HMQC: Heteronuclear Multiple Quantum Correlation Spectroscopy HRFABMS: High Resolution Fast Atom Bombardment Mass Spectroscopy HR-ES-IMS: High Resolution Electron Spray Ionization Mass Spectroscopy MWE/UPLC: MS/MS Microwave Extraction/ Ultra Performance Liquid Chromatography MTT: 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide NOESY: Nuclear Overhauser Effect Spectroscopy PO: Portulaca oleracea PUFA: Polyunsaturated fatty acids ROS: Reactive oxygen species TOCSY: Total Correlation Spectroscopy References Azuka OI, Ayalokunrin MB, Abu OL