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Currently, temozolomide (TMZ) is the first-line drug for GBM treatment of which efficacy is unfortunately hindered by short circulation time and drug resistance associated to hypoxia and redox tumor microenvironment

Two different chromatographic methods were used

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Glutathione(GSH), a major cellular antioxidant, is considered an inhibitor of theinflammatoryresponse involving reactive oxygen species (ROS)

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