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However, the efficacy of these treatments is not universally established

It calms inflammation while addressing the pigmentation that follows it

105 For parenteral supplementation vitamin B12 is administered as cyanocobalamin

J Biol Chem 282:3045265, PMID: 17724027 Ji L, Shen K, Jiang P, Morahan G, Wang Z (2011) Critical roles of cellular glutathione homeostasis and jnk activation in andrographolide-mediated apoptotic cell death in human hepatoma cells

That does not invalidate the findings, but it is relevant context for how to interpret them [19]
