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Key points Increased intestinal permeability occurs in a wide range of disorders, including inflammatory bowel disease, coeliac disease and graft-versus-host disease, but the relative contributions of barrier dysfunction and immune responses are unclear

Very low voiding frequencies or high voided volumes should prompt a diligent search for an alternate diagnosis

Any combination of these symptoms can make it harder to lose weight and sometimes even cause you to gain weight

Organ protection and toxicity counteraction: BPC-157 showed protective effects in numerous organ injury models