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Downstream tissue effects persist substantially longer

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This cell line has been successfully used in drug discovery and screening environments for studying GPCRs that do not conventionally couple through intracellular calcium

Androgen/AR complex binding to antioxidative response elements (AREs) containing promoters of target genes disrupts Wnt agonist/antagonist balance involved in DPC-inductive ability, such as dickkopf-1 (DKK1), which is a specific inhibitor of Wnt coreceptors of the LRP family 29

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