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GHK-CU is a copper(II)-complexed tripeptide (molecular weight: ~401 g/mol) consisting of glycine-histidine-lysine chelated to copper ions, naturally present in human plasma

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In addition, supplemental glutathione is typically highly reactive to oxidation, making it difficult to manufacture in a stabilised format

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To assess enhanced analgesia, the first assessment at time "0" was preceded by the application of morphine or saline 30 min before (time "-30 min"), by the application of haloperidol or saline 20 min (time "-20 min"), and, lastly, by the application of gastric pentadecapeptide BPC 157 or naloxone or saline (5 ml/kg i.p.) 10 min (time "-10 min")