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While drugs targeting ferroptosis hold promise, they also present challenges: (I) lack of specificity: where iron chelators may disrupt normal cellular iron metabolism and cause iron-deficiency anemia

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This multi-level intervention in oxidative processes contributes to their potent protective effects in reproductive tissues

Besides its directly oxidative activity, it is now clear that H 2 O 2 has a key signaling role in plants ( 2 O 2 can induce gene expression and modulates signaling proteins, such as protein phosphatases (PP), protein kinases (PK), transcription factors and calcium channels that are located in the plasma membrane or elsewhere (Neill et al., 2002

HDAC6 stands out within the HDAC family because of its large size and possession of two separate catalytic domains, CD1 and CD2, in addition to a zinc-finger domain (ZnF-UBP) that binds ubiquitin at the end of the protein (22)