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The consistent clinical failure of agents targeting a single mode of cell death provides compelling clinical validation for the mechanistic principle outlined in Section 2.4.2: MIRI triggers an interconnected web of cell death programs, suggesting future strategies may need to be multi-modal or target more upstream events

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While these effects are often cited by users, there is currently insufficient clinical evidence to show that combining them with Retatrutide improves recovery, sleep or long-term treatment outcomes

10.1039/c9sc01070j 72 XiangH.YouC.LiuW.WangD.ChenY.DongC

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