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Investigating curcumin anti-cancer effects through drug delivery system The therapeutic efficacy of curcumin, however, is restricted by its poor solubility, low absorption from the gut, rapid metabolism, and systemic elimination

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These findings emphasize the need of swift freezing or analysis of the metabolites, with a maximal time of four hours of exposure to room temperature to prevent significant metabolite dynamics in vitro

Exclusion Criteria: diarrhea or oral antibiotic intake within the previous 4 weeks

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