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Description
This possibility is supported by the findings of Ricciolini et al
Additionally, the highest incidence of AEs occurred in a triple-blind, cross-controlled trial in which LC was used to alleviate migraine symptoms, with approximately 33% of subjects reporting mild or moderate AEs
Asian-Australas J Anim Sci
These changes in the LC levels observed in rats and mice are in agreement with the aforementioned VPA mechanism that leads to LC depletion, and the consequential increase in the AC/LC ratio reflecting mitochondrial dysfunction
Treatment involves chronic immune suppression similar to other vasculitides
