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In the hypothalamus, LC has been reported to decrease neuronal cell death and damage associated with aging [78] by its cholinomimetic activity [79]

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Epidemiological studies showed that genes contribute to the vulnerability of multiple CNS disorders, such as major depressive disorders (MDD), schizophrenia and substance use disorders with heritability respectively of 3142%, 6480%, and 2379% [10,11,12,13]

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Other medications can inhibit OCTN2 leading to secondary carnitine deficiency, for example anticancer drugs (etoposide, actinomycin D and vinblastine), omeprazole, -lactam antibiotics (cephaloridine, cefepime, and cefluprenam), and quinolone antibiotic (levofloxacin and grepafloxacin) [13, 153155]

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