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So, it could be concluded that upon conjugation with glutathione, the selectivity of epothilone towards the tumor cell lines was strongly increased by two folds, ensuring the higher solubility of the conjugate that facilitates the penetration of the drugs across the plasma membrane via the ATP-Binding Cassette (ABC) proteins ABCC1 that called GSH-S-conjugate pump [6]

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BioRad, Hercules, USA), immunoblots were developed using Pierce ECL Western Blotting Substrate (Thermo Scientific, USA)

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