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Such a situation may indicate that, under HuR depletion conditions, in addition to having increased glutaminase activity (dictated by higher levels of a more active glutaminase), cells also present increased shuttling of glutamine carbons into the TCA cycle, which may be a result of the alteration in the activity of other enzymes

However, all of the abovementioned changes occurred independently of any change in body composition or hemodynamic parameters

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However, since these data are derived from an animal model, it remains necessary to confirm these effects in humans before considering a clinical application

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