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doi: 10.1016/j.coi.2020.09.007

B12 is also crucial for neurotransmitter function, improving mood and mental focus
Many systems require multiple provider evaluations before specialist referral, each adding weeks or months to the diagnostic timeline

TrkB-BDNF neurotrophin signalling: Semax-induced BDNF binds TrkB receptors on target neurons: TrkB phosphorylation (pTrkB Y706/707) +1.61.8

Acute ischaemic stroke mixed, leaning cautious The 2023 Cochrane review found no clear clinical benefit and a moderate-certainty signal of more non-fatal serious adverse events
