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For most healthy adults taking CLA and L-carnitine together at commonly studied doses is likely tolerated in the short term

In particular, she says these two increase the efficacy of vitamin C and help stabilize it

The run-in phase involved pre-weight-loss assessments (PRE), reducing energy intake to 60% of estimated weight-maintenance needs (to achieve weight loss of 12 2% relative to PRE body weight), stabilizing body weight after weight loss, and conducting assessments again at random assignment (START)

In other words, the darkening of the skin is a visible sign that damage has already occurred

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