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Transporter dysfunction within the endolysosomal system leads to diverse systemic phenotypes

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NQO1 is associated with the 20S proteasome (31) and regulates the stability of numerous intrinsically disordered proteins (IDPs) such as p53, p73, and PGC1 in an NADH-dependent manner (19,31)

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Nat Protoc 2: 22852294 Girkontaite I, Urbonaviciute V, Maseda D, Neubert K, Herrmann M, Voll RE (2007) Apoptotic cells selectively suppress the Th1 cytokine interferon gamma in stimulated human peripheral blood mononuclear cells and shift the Th1/Th2 balance towards Th2