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Biochim Biophys Acta 1850:16421660 Florian S, Krehl S, Loewinger M, Kipp A, Banning A, Esworthy S, Chu FF, Brigelius-Floh R (2010) Loss of GPx2 increases apoptosis, mitosis, and GPx1 expression in the intestine of mice

These enzymes include malic enzyme 1 (ME1) and IDH1, which generate NADPH, and thus the levels and subcellular compartmentalization of malate and isocitrate dictate the activity of these enzymes