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This resistance is mediated by different causes and mechanisms, (that are resumed in Table 1 and excellently summarized in different review articles [78].One of the most obvious and intriguing mechanisms of resistance involves alteration in CD38 expression, a crucial factor in both primary and acquired resistance to anti-CD38 therapies

When triglycerides are broken down and released from fat cells, the cells shrink but dont disappear

The maintenance dose can be around 500-1000mg if the initial loading was successful, and can be adjusted based on frequency as well (500mg weekly or 1000mg every 2 weeks)