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High concentrations of cytotoxic BAs (e.g., DCA) can drive microbial transcriptional reprogramming, including upregulation of efflux pumps and stress response genes, and alterations in core metabolism and BA-modifying enzyme expression (122)

Sobesky R, Guillaud O, Bouzbib C, et al

The critical coagulation concentration (CCC) depends on the charge valency (Z) of counterions, with CCC proportional to Z 6

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Although it is well known that leptin plays a central role in regulating energy balance by suppressing food intake and promoting energy expenditure, the existence of leptin resistance in majority of obese individuals hampers the utilization of leptin therapy against these disorders