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David Sinclair notes in his work: "NAD+ is pivotal for sirtuins and aging reversal

Loss of NAD homeostasis leads to progressive and reversible degeneration of skeletal muscle

Meanwhile, research on synergistic effects with other anti-aging substances will be further deepened, providing important support for establishing multi-target, multi-pathway anti-aging intervention systems

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Increased flux of key cellular energy regulators, including NAD + and SAM, may potentially define the therapeutic mechanism-of-action of NNMT inhibitors