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In addition, an excessive amount of this essential metal induces toxicity, leading to pathological conditions generated by oxidative stress and neurodegeneration [128]

Daniel Drucker at the University of Toronto demonstrated that GLP-1 receptor agonists have cardiovascular protective effects independent of glucose control or weight loss, work that fundamentally expanded the indication beyond diabetes into cardioprotection

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Importantly, iron accumulation within microglia drives them toward a pro-inflammatory M1 state, which not only exacerbates neuroinflammation and DA neuronal loss but also establishes a vicious cycle involving inflammasome activation and ferroptosis (Yu et al., 2023)