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[DOI] [PMC free article] [PubMed] [Google Scholar] 20.Placzek M., Gaube S., Kerkmann U., Gilbertz K.P., Herzinger T., Haen E., Przybilla B

(A-B) Unlike wild type, glo-1(-) mutants lacked birefringent material in intestinal cells, misaccumulating it within the intestinal lumen (black arrow), lacked PGP-2 marked organelles, and lacked autofluorescent gut granules

T helper type 1 (T H 1) cells promote atherosclerosis, regulatory T cells are protective and T H 17 cells promote plaque stability Many connections between the immune system and metabolism exist

2,3 Hepatomegaly and splenomegaly are seen in nearly all children and adults with LAL-D

Given the limited reports of bivalent functional effects, further studies may be warranted to investigate the mechanism of bivalent ligands' functional signaling and how they may differ from monovalent ligands
