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281 The key targets of the TLR pathway and their related regulatory mechanisms are shown in Fig

Free heme is assigned many toxic actions, such as being a pro-oxidant [21,22,211], pro-inflammatory [212,213] and vaso-occlussive agent [214,215] that causes the depletion of NO [216] and oxidation of serum lipoproteins (atheromatosis) [21]

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Zhang et al., Multispectral optoacoustic imaging of dynamic redox correlation and pathophysiological progression utilizing upconversion nanoprobes

Testing includes High-Performance Liquid Chromatography (HPLC) for purity, and Mass Spectrometry (MS) for sequence confirmation
