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Among them, the cytosolic enzyme nicotinamide N-methyltransferase (NNMT) has been newly discovered to regulate the levels of nicotinamide precursors required for NAD+ biosynthesis, and therefore plays a crucial role in regulating the NAD+ salvage pathway and cellular metabolism

doi: 10.1038/nature17184

However, no controlled trials support these claims in humans

[DOI] [PubMed] [Google Scholar] 165.Bridges, K

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