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The exact therapeutic effects require indepth research (Martemucci et al

Among the four expressed chimeras, M2 (the C-terminus of L0) and M5 (N-terminus half of L1), kept to a certain extent their ability to transport GSH in a stimulated manner and consequently to sensitize cells to GSH-depleting agents despite their relatively low expression compared to wild-type MRP1

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1 2 3 4 Lehninger Principles of Biochemistry

Histone acetylation plays a major role in regulating the chromatin structure around the DSB that is required for both chromatin relaxation and efficient recruitment of DSB repair proteins as well as promoting transcription of DNA repair genes