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In various cell lines, bupivacaine has been reported to hinder the functions of mitochondrial respiratory chain complexes I and III [102], potentially inducing excessive activation of mitochondrial mPTP channels [103], which can lead to mitochondrial depolarization and cell apoptosis [104]

Scientific Context and Research Significance Synthetic peptides such as DSIP are valuable research tools because their defined molecular structures allow researchers to isolate specific biochemical signaling pathways

Some other minor compounds are maslinic acid, terflavin A, punicalagin, and galloyl glucose, like polyphenols [17]

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