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In various cell lines, bupivacaine has been reported to hinder the functions of mitochondrial respiratory chain complexes I and III [102], potentially inducing excessive activation of mitochondrial mPTP channels [103], which can lead to mitochondrial depolarization and cell apoptosis [104]

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Scientific Context and Research Significance Synthetic peptides such as DSIP are valuable research tools because their defined molecular structures allow researchers to isolate specific biochemical signaling pathways

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Some other minor compounds are maslinic acid, terflavin A, punicalagin, and galloyl glucose, like polyphenols [17]

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