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Concomitantly, metabolomic analysis showed significant differences between aged WT and Mda5 -/- HSCs

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To this end, we expressed exogenous NRF2-FL in Hs578 cells and analyzed the transcriptome after 8 h of Cyss deprivation in comparison to cells grown in the presence of Cyss and to cells expressing GFP as a control and treated in the same manner (Fig

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