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The primary concern for the FDA was the lack of large-scale, randomized controlled trials, which are the gold standard for new drug approval

NR works as a precursor to nicotinamide adenine dinucleotide (NAD+), rather than being NAD+ itself

Preclinical evidence consistently demonstrates its potential to accelerate healing across multiple tissue types through mechanisms involving angiogenesis, growth factor modulation, and anti-inflammatory effects

A high "cytoprotective capacity", apparently acid independent, common for all tested agents but clearly more prominent for NaBPC157 is evident

References In combination with PRP injections, this saved me from rotator cuff surgery and got me back to work