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Sepesi B, Correa AM, Pataer A, Kalhor N, Bekele BN, Erasmus JJ, Hofstetter WL, Kim ES, Komaki R, Mehran RJ, Moran CA, Papadimitrakopoulou V, Rice DC , Roth JA, Vaporciyan AA, Walsh GL, William WN, Wistuba I, Swisher SG

In the tissue samples, we assessed oxidative stress by quantifying the thiobarbituric acid (TBA) reactivity as malondialdehyde equivalents (MDA)

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This creates a unique metabolic dance that the body needs time to adjust to, which is why the retatrutide dose schedule uses a gradual titration over many weeks

For a cardiovascular performance assay, six endpoints were chosen to evaluate the cardiovascular performance in the zebrafish larvae: the heart rate and time interval in ventricles, stroke volume, cardiac output, ejection fraction, and shortening fraction