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Systemic pharmacological treatment with dexamethasone (an NMDAR and ROS inhibitor) was found to prevent neuronal apoptosis in BIPN ( 4.1.4 Additional pharmacological studies Studies have demonstrated that ethosuximide as a T-type calcium channel inhibitor effectively alleviates abnormal pain in BIPN (Tomita et al., 2019)

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Several studies have shown that TGF-1 upregulates glutaminase 1 (GLS1), enhancing the conversion of glutamine to glutamate, a critical step for collagen biosynthesis [97,98,99]

While understanding of IBD is still limited, it is believed that CD is mediated largely by Th1 responses, although Th17 responses are emerging more and more as an important contributor to the disease development and progression (68)

Their effects on weight loss may be due to other mechanisms and methods of administration