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for instance, certain vitamin B-dependent epilepsies necessitate doses up to 100-600 mg per day to control seizures, with long-term supplementation of about 30 mg daily for life to prevent symptom recurrence

Therefore, it can have a toxic effect on -synuclein fibrillation by increasing the number of oligomeric species and protofibrils rather than full length fibrils (Kumari et al., 2022)

In SRS, there is a normal postnatal expression of the IGF2 gene in the liver leading to normal levels of circulating IGF-II

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