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The preclinical evidence, while promising, has not progressed to FDA-registered clinical trials for TB-500, and PubMed searches for TB-500 regulatory warnings between 2015-2026 consistently return the same conclusion: no certificate of analysis exists in any FDA database for TB-500 as an approved drug product, and researchers working with this compound should rely on vendor-provided third-party COAs for verification

Additionally, lobetyolin has been found to induce apoptosis in colon cancer cells by inhibiting ASCT2 (He et al., 2020)

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