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Recent studies have shown that treatment of SOD1 G93A mice with naturally occurring flavonoids fisetin and 7,8-dihydroxyflavone, inhibits ROS production and neurodegeneration by activating the ERK signaling pathway (Korkmaz et al., 2014

Some of the most common causes include: Chronic stress and high cortisol Poor or fragmented sleep Hormonal imbalances, including thyroid issues Dehydration Post-viral fatigue, including Long COVID Blood sugar spikes and crashes Nutritional deficiencies, particularly vitamin B12, iron, and vitamin D That last category is where things get interesting

Here, we demonstrate that the GST tag is a substrate of transglutaminase 2 (TG2), which is a calcium-dependent enzyme that polyaminates or crosslinks substrate proteins

It stimulates collagen, dermatan sulfate, chondroitin sulfate, and the small proteoglycan, decorin

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