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It helps convert Vitamin D into its active form and is essential for bone structure

Considering that AIF3 splicing caused mitochondrial complex disassembly and induced genes involved in OXPHOS and ROS pathways, we next examined the effect of AIF3 splicing on cellular ROS levels in WT and AIF3 splicing MEFs in the presence or absence of H 2 O 2 treatment (250 M, 2 h) using MitoSOX staining

3.3 Nrf2 pathway Nrf2 assumes a critical role by activating the body's antioxidant response through binding to antioxidant response elements (ARE) in the promoter regions of numerous genes responsible for cellular protection (48)

This review will serve as concise literature to evaluate the trend and potential of melatonin as nephroprotective adjunct in drug-induced nephrotoxicity

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