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doi: 10.1093/ajcp/95.4.484 9 Prieto-RodrguezMCamaas-SanzABasTCortesBVera-SempereFJ

4 Actinic lentigo Clinical features Actinic lentigines (also known as lentigo senilis, solar lentigo, senile freckle, senile lentigo, liver spot) are benign, irregular, macular lesions that commonly develop on sun-damaged skin of the middle aged and elderly, and are therefore most numerous on the face and dorsal aspects of the hands and forearms (Figs 25.13, 25.14)

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VDACs interaction with ANT forms the mitochondrial permeability transition pore (MPTP), which is located primarily at mitochondrial contact sites and regulates the cells response to apoptotic events