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These protective compounds, including flavonoids, phenols, vitamin E, and ellagic acid, neutralize free radicals that drive oxidative stress, one of the primary triggers of cartilage breakdown and chronic joint inflammation

Through the formation of ONOO or ONOO -derived radical (NO 2 ), NO is indirectly responsible for irreversible damage to protein residues such as tyrosine nitration

H3K27ac modification is closely associated with transcriptional gene activation, and ChIP-qPCR data showed that miR-214 increased the enrichment of H3K27ac at the proximal promoter regions of ACSL4 , SLC38A1 and PRKAA2 (Fig

K., Malmstrm, J., Hjlys-Larsen, K