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The downregulation of HSP70/BAG3 by fisetin significantly reduced the amounts of Bcl-2, Bcl-xL and Mcl-1 proteins, subsequently inducing apoptotic cell death
143 ZhangH.DaiY.ChengY.HeY.ManyakaraZ.DuanY.et al (2017a)
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One of the possible contributing factors, which is p53 (p53 plays a role in regulating cell cycle, DNA repair, and apoptosis), controls Bcl2/BAX and also other main genes related to apoptosis
This section will highlight several key ferroptosis targets, as illustrated in Fig
