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These mutations include gain-of-function mutations of the MC2R, GNAS, the catalytic subunit of protein kinase A (PRKACA) and PRKACB genes and inactivating mutations of the regulatory subunit R1 of PKA ( PRKAR1A ), and of two cAMP-binding phosphodiesterases ( PDE11A and PDE8B ) genes, mimicking the action of ACTH to stimulate glucocorticoid production, providing a molecular basis for the pathogenesis of primary adrenal Cushing syndrome (22)

Non-Robertsonian translocations involving chromosomes 13, 14, or 15 in male infertility: 28 cases and a review of the literature

Due to its structural similarities with vitamin K, CoQ10 may selectively interact with cytochrome P450 enzymes, reducing response to warfarin (Sharma et al., 2016)

In patients with DKD, the expression level of messenger RNA (mRNA) encoding IL6 is positively correlated with the degree of dilatation of the thylakoid glands (Suzuki et al., 1995), which is a characteristic histologic feature of the disease (Ma et al., 2024)