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GHK-Cu, first identified in 1973 from mammalian plasma, functions as a naturally occurring copper-peptide complex that influences approximately 31% of the human genome, resetting gene expression patterns to favor tissue repair while delivering bioavailable copper essential for enzymatic processes underlying collagen synthesis and antioxidant defense

Background Exercise induces changes in several organs and tissues, and this process might be due to oxidative damage caused by free radicals and inflammatory mediators

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The biotoxin cholera toxin is capable of inducing differentiation of U87-MG human glioblastoma cells, which is characterized by morphological changes to astrocytic phenotype, increase in differentiation marker protein GFAP and decrease in proliferation